Senglea is a fortified city in the east of Malta, mainly in the Grand Harbour area. It is one of the Three Cities, with the other two being Cospicua and Vittoriosa. The city of Senglea is also called Civitas Invicta, because it managed to resist the Ottoman invasion at the Great Siege of 1565.

With an area of just over half a square mile, it is Malta's smallest locality. It is also its most densely populated. At the turn of the century, Senglea had more than 8200 people, making it the most densely populated town in Europe. At the time, Senglea, as well as Cospicua, were the centre of Malta's elite and intelligentsia. The Second World War rapidly altered its social structure as many left to take refuge in outlying towns and countryside, never to return. In recent years, rehabilitation of the Cottonera Waterfront as a yacht marina has spurred a lot of interest from foreign expatriates and businessmen.

The city is noted for its superb harbour views across to Valletta from Safe Haven Gardens at Senglea Point.

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